Erbb2 Gene Summary [Mouse]
Enables coreceptor activity and protein tyrosine kinase activity. Involved in several processes, including ERBB2 signaling pathway; nervous system development; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within several processes, including negative regulation of immature T cell proliferation in thymus; nervous system development; and neuromuscular junction development. Located in apical plasma membrane; cytoplasmic vesicle; and myelin sheath. Part of semaphorin receptor complex. Is active in neuromuscular junction and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Hirschsprung's disease; breast cancer; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including lung cancer (multiple); mammary Paget's disease; reproductive organ cancer (multiple); stomach cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Erbb2 |
| Official Name | erb-b2 receptor tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:95410] |
| Ensembl ID | ENSMUSG00000062312 |
| Bio databases IDs | |
| Aliases | erb-b2 receptor tyrosine kinase 2 |
| Synonyms | 1 NDF1, CD340, c-ERB-2, C-erb-b2, c-neu, EGFR2, epidermal growth factor receptor 2, ERBB2 receptor, erb-b2 receptor tyrosine kinase 2, HER-2, HER-2 (ERBB2), HER2/Neu, l11Jus8, LOC102552659, mKIAA3023, MLN-19, NEU, NGL, p185(erbB2), p185HER2, TKR1, V-ERBB2 NEURO/GLIOBLASTOMA-DERIVED ONCOGENE, VSCN2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Erbb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Erbb subdomain 4
- Furin-like cysteine rich region
- ATP-binding domain
- heat shock protein binding
- TM_EGFR-like
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- Grb2 binding domain
- FU
- cytoplasmic domain
- receptor tyrosine kinase binding
- Bcl-2 homology 3 domain
- intracellular domain
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- growth factor binding
- transmembrane receptor
- SHP-2 binding domain
- coreceptor
- cytoplasmic kinase domain
- extracellular domain
- ubiquitin protein ligase binding
- Protein kinase (unclassified specificity)
- Growth factor receptor domain IV
- Protein tyrosine and serine/threonine kinase
- catalytic domain
- ectodomain
- enzyme binding
- autophosphorylation site
- protein binding
- receptor binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Receptor L domain
- binding protein
- Shc binding site
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- transmembrane domain
- Furin-like repeats
- cytosolic tail domain
- PDZ binding motif
- substrate binding domain
- protein heterodimerization
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Erbb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Endometrial Cancer Signaling
- ErbB Signaling
- ErbB2-ErbB3 Signaling
- FAK Signaling
- HER-2 Signaling in Breast Cancer
- IL-15 Production
- Neuregulin Signaling
- Non-Small Cell Lung Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Sperm Motility
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- recurrent ovarian cancer
- advanced non-small cell lung cancer
- metastatic non-small cell lung cancer
- non-small cell lung carcinoma
- CD30 positive anaplastic large cell lymphoma
- advanced lung squamous cell carcinoma
- lung carcinoma
- locally advanced non-small cell lung cancer
- stage IV lung squamous cell carcinoma
- advanced large cell lung carcinoma
role in cell
- expression in
- growth
- accumulation
- phosphorylation in
- activation in
- cell death
- apoptosis
- cell viability
- proliferation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- postsynaptic density (PSD) fractions
- detergent-insoluble fractions
- membrane fraction
- cholinergic bouton
- Cytoplasm
- cell surface
- Extracellular Space
- cell periphery
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- Mitochondria
- cytosol
- lateral cell surfaces
- apical membrane
- presynaptic membrane
- postsynaptic membrane
- caveolae
- synaptic membrane
- plasma membrane projections
- basolateral membrane
- basal membrane
- endosomal membrane
- nucleoplasm
- nucleoli
- neurofilaments
- neuromuscular junctions
- myelin sheath
- synaptosomes
- cytoplasmic vesicles
- membrane blebs
- transverse tubules
- membrane rafts
- cellular protrusions
- microvilli
- filopodia
- perikaryon
- plasma
- lamellipodia
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Erbb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- peptidyl-tyrosine phosphorylation
- ERBB2-ERBB4 signaling pathway
- positive regulation of translation
- positive regulation of Rho protein signal transduction
- positive regulation of protein targeting to membrane
- Schwann cell development
- motor axon guidance
- negative regulation of immature T cell proliferation in thymus
- multicellular organismal development
- ERBB2-EGFR signaling pathway
- ERBB2-ERBB3 signaling pathway
- positive regulation of cell proliferation
- regulation of angiogenesis
- neurogenesis
- myelination
- positive regulation of cell adhesion
- protein phosphorylation
- immature T cell proliferation in thymus
- positive regulation of transcription from RNA polymerase I promoter
- neuromuscular junction development
- heart development
- positive regulation of cell growth
- wound healing
- protein kinase B signaling cascade
- positive regulation of kinase activity
- positive regulation of epithelial cell proliferation
- intracellular signal transduction
- regulation of microtubule-based process
- oligodendrocyte differentiation
- signal transduction
- neuron differentiation
- transmembrane receptor protein tyrosine kinase signaling pathway
- cell surface receptor signaling pathway
- enzyme linked receptor protein signaling pathway
- positive regulation of MAPK cascade
- regulation of ERK1 and ERK2 cascade
- negative regulation of apoptotic process
- cellular response to growth factor stimulus
- cellular response to epidermal growth factor stimulus
- positive regulation of protein phosphorylation
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- myelin sheath
- ERBB3:ERBB2 complex
- receptor complex
- plasma membrane
- nucleoplasm
- nucleus
- semaphorin receptor complex
- early endosome
- basal plasma membrane
- perinuclear region of cytoplasm
- membrane
- ruffle membrane
- cytosol
- neuromuscular junction
- endosome membrane
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- growth factor binding
- identical protein binding
- ErbB-3 class receptor binding
- receptor binding
- ATP binding
- protein tyrosine kinase activity
- transmembrane signaling receptor activity
- protein binding
- RNA polymerase I core binding
- transmembrane receptor protein tyrosine kinase activity
- protein heterodimerization activity
- receptor tyrosine kinase binding