Miox Gene Summary [Mouse]
Enables aldo-keto reductase (NADPH) activity and oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in inositol catabolic process. Located in cytoplasm. Is expressed in cortical renal tubule; metanephros; primitive collecting duct; and renal medulla. Orthologous to human MIOX (myo-inositol oxygenase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Miox |
| Official Name | myo-inositol oxygenase [Source:MGI Symbol;Acc:MGI:1891725] |
| Ensembl ID | ENSMUSG00000022613 |
| Bio databases IDs | |
| Aliases | myo-inositol oxygenase |
| Synonyms | 0610009I10Rik, ALDRL6, C85427, myo-inositol oxygenase, RSOR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Miox often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADH or NADPH oxidoreductase
- ferric iron binding
- inositol oxygenase
- NADP binding
- aldo-keto reductase
- oxidoreductase
- enzyme
- Myo-inositol oxygenase
Pathways
Biological processes and signaling networks where the Miox gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- acute lymphoblastic leukemia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- breast adenocarcinoma
- papillary thyroid carcinoma
- papillary thyroid cancer
- primary cardiomyopathy
- Marfan syndrome
- primary cancer
regulated by
- streptozocin
- sorbitol
- myo-inositol
- D-glucose
- thioacetamide
- hydrogen peroxide
- H89
- taurine
- beta-naphthoflavone
- pyruvaldehyde
role in cell
- generation in
- elongation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Miox gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- inclusion body
Molecular Function
What the gene product does at the molecular level
- inositol oxygenase activity
- ferric iron binding
- aldo-keto reductase (NADP) activity
- oxidoreductase activity, acting on NADH or NADPH