Ubr4 Gene Summary [Mouse]
Enables calmodulin binding activity and ubiquitin protein ligase activity. Involved in endosome organization; positive regulation of autophagy; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Acts upstream of or within protein catabolic process and protein stabilization. Located in endosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human UBR4 (ubiquitin protein ligase E3 component n-recognin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubr4 |
| Official Name | ubiquitin protein ligase E3 component n-recognin 4 [Source:MGI Symbol;Acc:MGI:1916366] |
| Ensembl ID | ENSMUSG00000066036 |
| Bio databases IDs | |
| Aliases | ubiquitin protein ligase E3 component n-recognin 4 |
| Synonyms | 1810009A16Rik, A930005E13Rik, D930005K06Rik, Gm1032, Gm1666, LOC148490, mKIAA0462, p600, RBAF600, ubiquitin protein ligase E3 component n-recognin 4, ZUBR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative zinc finger in N-recognin (UBR box)
- Putative zinc finger in N-recognin
- E3 ubiquitin-protein ligase UBR4 N-terminal
- calmodulin binding
- ubiquitin protein ligase activity
- E3 ubiquitin-protein ligase UBR4
- UBR-box
- enzyme
- protein binding
- E3 ubiquitin ligase domain
- Double zinc ribbon
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- soft tissue sarcoma
- soft tissue sarcoma cancer
- sickle cell anemia
role in cell
- apoptosis
- formation
- accumulation in
- organization
- autophagy by
- activation in
- degradation in
- turnover in
- CSN5i-3 sensitivity
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- double-membrane vesicle
- Cytoplasm
- Plasma Membrane
- endosomes
- centrosome
- secretory granule membrane
- tertiary granule membrane
- specific granule membrane
- cytosol
- nucleoplasm
- synaptosomes
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fatty acid biosynthetic process
- positive regulation of autophagy
- proteasomal ubiquitin-dependent protein catabolic process
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
- endosome organization
- ubiquitin-dependent protein catabolic process via the N-end rule pathway
- protein K27-linked ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- endosome
- cytoplasm
- membrane
- cytosol
- tertiary granule membrane
- plasma membrane
- specific granule membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- calmodulin binding
- zinc ion binding
- protein binding