Slc22a1 Gene Summary [Mouse]
Enables several functions, including organic cation transmembrane transporter activity; pyrimidine nucleoside transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including monoamine transport; quaternary ammonium group transport; and spermidine transport. Acts upstream of or within monoatomic cation transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including adrenal gland; liver; mammary gland; metanephros; and nasal cavity mucosa. Orthologous to human SLC22A1 (solute carrier family 22 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Slc22a1 |
| Official Name | solute carrier family 22 (organic cation transporter), member 1 [Source:MGI Symbol;Acc:MGI:108111] |
| Ensembl ID | ENSMUSG00000023829 |
| Bio databases IDs | |
| Aliases | solute carrier family 22 (organic cation transporter), member 1 |
| Synonyms | Lx1, Oct1, Orct, Orct1, solute carrier family 22 (organic cation transporter), member 1 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc22a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dopamine:sodium symporter
- organic cation porter
- benzoate transport
- pyrimidine nucleoside transporter
- MFS transporter, sugar porter (SP) family
- Multidrug resistance protein
- Major Facilitator Superfamily
- neurotransmitter transporter
- organic anion transporter
- identical protein binding
- prostaglandin transporter
- noradrenaline:sodium symporter
- organic cation transporter
- monoamine transporter
- Sugar (and other) transporter
- xenobiotic transporter
- spermidine transporter
- thiamin transporter
- acetylcholine transporter
- toxin transporter
- carnitine transporter
- cation transport protein
- transporter
- putrescine transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane