Lgr4 Gene Summary [Mouse]
Enables transmembrane signaling receptor activity. Involved in several processes, including metanephric nephron development; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; intestinal stem cell homeostasis; and male genitalia development. Located in plasma membrane. Is expressed in several structures, including alimentary system; eye; integumental system; metanephros; and telencephalon. Used to study glaucoma. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lgr4 |
| Official Name | leucine-rich repeat-containing G protein-coupled receptor 4 [Source:MGI Symbol;Acc:MGI:1891468] |
| Ensembl ID | ENSMUSG00000050199 |
| Bio databases IDs | |
| Aliases | leucine-rich repeat-containing G protein-coupled receptor 4 |
| Synonyms | 9130225G07, A330106J01RIK, A930009A08Rik, BNMD17, DPSL, GPCR48, GPR48, leucine-rich repeat-containing G protein-coupled receptor 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lgr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- G-protein coupled receptor
- extracellular domain
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- ectodomain
- Leucine rich repeat
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
- leucine-rich repeat
- 7 transmembrane receptor (rhodopsin family)
- Leucine rich repeat N-terminal domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Lgr4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colon carcinoma
- osteoporosis
- prostate cancer
- adenomyosis
- metastasis
- hypoplasia
- growth failure
- lung adenocarcinoma
- lung adenocarcinoma formation
phenotypes
- abnormal anterior eye segment morphology
- abnormal canal of Schlemm morphology
- abnormal caput epididymis morphology
- abnormal cornea morphology
- abnormal corneal epithelium morphology
- abnormal corneal stroma morphology
- abnormal efferent ductules of testis morphology
- abnormal epidermal stem cell proliferation
- abnormal epididymal fat pad morphology
- abnormal epididymis epithelium morphology
- abnormal epididymis morphology
- abnormal glomerular capsule space morphology
- abnormal intestine development
- abnormal intestine physiology
- abnormal iridocorneal angle
- abnormal keratinocyte physiology
- abnormal kidney morphology
- abnormal lens morphology
- abnormal metanephric mesenchyme morphology
- abnormal metanephric ureteric bud development
- abnormal nephron morphology
- abnormal reproductive system morphology
- abnormal reproductive system physiology
- abnormal rete testis morphology
- abnormal retina morphology
- abnormal seminiferous tubule epithelium morphology
- abnormal skin development
- abnormal sperm number
- abnormal testis morphology
- abnormal testis physiology
- anterior iris synechia
- asthenozoospermia
- cataract
- ciliary body hypoplasia
- corneal deposits
- corneal epithelium hypoplasia
- corneal opacity
- corneal vascularization
- decreased body size
- decreased body weight
- decreased cornea thickness
- decreased corneal epithelium thickness
- decreased corneal stroma thickness
- decreased epididymal cell proliferation
- decreased epididymis weight
- decreased fetal weight
- decreased hair follicle number
- decreased kidney weight
- decreased liver weight
- decreased renal glomerulus number
- decreased survivor rate
- dilated renal tubules
- dilated rete testis
- disorganized retinal inner nuclear layer
- disorganized retinal outer nuclear layer
- disorganized secondary lens fibers
- embryonic growth retardation
- enlarged testis
- enlarged uterus
- epididymal cyst
- epididymis hypoplasia
- eyelids open at birth
- hypoplastic trabecular meshwork
- impaired branching involved in ureteric bud morphogenesis
- increased circulating creatinine level
- increased incidence of corneal inflammation
- increased kidney apoptosis
- increased testis weight
- infertility
- iris hypoplasia
- iris stroma hypoplasia
- kidney cysts
- lethality throughout fetal growth and development incomplete penetrance
- male infertility
- microphthalmia
- mydriasis
- neonatal lethality incomplete penetrance
- perinatal lethality complete penetrance
- perinatal lethality incomplete penetrance
- polycystic kidney
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- premature death
- prenatal lethality incomplete penetrance
- reduced female fertility
- renal hypoplasia
- rete testis obstruction
- retinal ganglion cell degeneration
- small caput epididymis
- small lens
- small metanephros
- thin epidermis
- thin retinal inner nuclear layer
- thin retinal outer nuclear layer
role in cell
- invasion by
- degradation in
- expression in
- proliferation
- migration
- phosphorylation in
- apoptosis
- binding in
- quantity
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lgr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone remodeling
- bone mineralization
- negative regulation of toll-like receptor signaling pathway
- spermatogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- metanephric nephron tubule morphogenesis
- positive regulation of branching involved in ureteric bud morphogenesis
- circadian regulation of gene expression
- metanephric glomerulus development
- hair follicle development
- male genitalia development
- digestive tract development
- innate immune response
- osteoblast differentiation
- Wnt receptor signaling pathway
- negative regulation of cytokine production
- epithelial cell proliferation involved in renal tubule morphogenesis
- activation of adenylate cyclase activity
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- G-protein coupled peptide receptor activity
- protein binding
- transmembrane signaling receptor activity
- protein-hormone receptor activity