Nudt3 Gene Summary [Mouse]
Enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity and 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity. Involved in RNA decapping. Is active in glutamatergic synapse. Orthologous to human NUDT3 (nudix hydrolase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nudt3 |
| Official Name | nudix (nucleotide diphosphate linked moiety X)-type motif 3 [Source:MGI Symbol;Acc:MGI:1928484] |
| Ensembl ID | ENSMUSG00000024213 |
| Bio databases IDs | |
| Aliases | nudix (nucleotide diphosphate linked moiety X)-type motif 3 |
| Synonyms | 1110011B09Rik, DIPP, DIPP-1, nudix hydrolase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nudt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NUDIX domain
- zinc ion binding
- pyrophosphatase
- diphosphoinositol-polyphosphate diphosphatase
- endopolyphosphatase
- phosphatase
- protein binding
- manganese ion binding
- magnesium ion binding
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- Nucleus
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nudt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- diadenosine polyphosphate catabolic process
- cell-cell signaling
- diphosphoinositol polyphosphate metabolic process
- diphosphoinositol polyphosphate catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- bis(5'-adenosyl)-hexaphosphatase activity
- diphosphoinositol-polyphosphate diphosphatase activity
- magnesium ion binding
- endopolyphosphatase activity
- inositol diphosphate pentakisphosphate diphosphatase activity
- inositol diphosphate tetrakisphosphate diphosphatase activity
- protein binding
- manganese ion binding
- inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
- bis(5'-adenosyl)-pentaphosphatase activity
- inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity