Sting1 Gene Summary [Mouse]
Enables 2',3'-cyclic GMP-AMP binding activity; cyclic-di-GMP binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to other organism; macroautophagy; and positive regulation of innate immune response. Acts upstream of or within cellular response to interferon-beta; positive regulation of transcription by RNA polymerase II; and regulation of inflammatory response. Located in several cellular components, including Golgi membrane; autophagosome; and perinuclear region of cytoplasm. Part of STING complex. Is active in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in ductus deferens; epididymis; ileum; liver; and prostate gland. Used to study STING-associated vasculopathy with onset in infancy. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sting1 |
| Official Name | stimulator of interferon response cGAMP interactor 1 [Source:MGI Symbol;Acc:MGI:1919762] |
| Ensembl ID | ENSMUSG00000024349 |
| Bio databases IDs | |
| Aliases | stimulator of interferon response cGAMP interactor 1 |
| Synonyms | 2610307O08Rik, ERIS, FLJ38577, hMITA, hSTING, MITA, MPYS, NET23, RGD1562552, rSTING, SAVI, stimulator of interferon response cGAMP interactor 1, STING, STING-beta, STING-β, TMEM173 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sting1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- cyclic nucleotide binding
- nucleotide binding
- protein kinase binding
- C-terminal domain of STING
- protein binding activity, bridging
- transcription factor binding
- STING-like
- protein binding
- purine nucleotide binding
- identical protein binding
- ion channel
- hydrogen ion channel
- binding protein
- ligand-binding domain
- adenyl nucleotide binding
- guanyl nucleotide binding
- protein homodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- epithelial neoplasia
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- non-insulin-dependent diabetes mellitus
role in cell
- signaling in
- binding in
- proliferation
- recruitment
- migration
- expression in
- cellular infiltration by
- cell death
- apoptosis
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- cilia
- cell surface
- perinuclear region
- cellular membrane
- Plasma Membrane
- basal bodies
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- secretory granule membrane
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- mitochondrial outer membrane
- nucleoplasm
- autophagic vacuoles
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sting1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- positive regulation of protein binding
- positive regulation of type I interferon production
- positive regulation of type I interferon-mediated signaling pathway
- positive regulation of defense response to virus by host
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- pattern recognition receptor signaling pathway
- autophagic vacuole assembly
- cytoplasmic pattern recognition receptor signaling pathway
- cellular response to exogenous dsRNA
- activation of innate immune response
- positive regulation of interferon-beta production
- innate immune response
- regulation of inflammatory response
- defense response to virus
- protein localization in endoplasmic reticulum
- cellular response to organic cyclic compound
- protein oligomerization
- cellular response to interferon-beta
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- mitochondrial outer membrane
- autophagic vacuole
- plasma membrane
- autophagic vacuole membrane
- nucleoplasm
- endoplasmic reticulum membrane
- peroxisome
- secretory granule membrane
- cytoplasmic vesicle membrane
- endosome
- perinuclear region of cytoplasm
- cytosol
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- ubiquitin protein ligase binding
- protein binding
- protein homodimerization activity
- signaling adaptor activity
- hydrogen ion channel activity
- cyclic-di-GMP binding