Fgf14 Gene Summary [Mouse]
Predicted to enable growth factor activity; heparin binding activity; and sodium channel regulator activity. Acts upstream of or within several processes, including adult locomotory behavior; neuromuscular process; and positive regulation of sodium ion transport. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; respiratory system; and sensory organ. Used to study Alzheimer's disease; frontotemporal dementia; and spinocerebellar ataxia type 27. Human ortholog(s) of this gene implicated in autosomal dominant cerebellar ataxia. Orthologous to human FGF14 (fibroblast growth factor 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf14 |
| Official Name | fibroblast growth factor 14 [Source:MGI Symbol;Acc:MGI:109189] |
| Ensembl ID | ENSMUSG00000025551 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 14 |
| Synonyms | Fgf1b, FHF-4, fibroblast growth factor 14, mFHF-4(1B), NYS4, SCA27, SCA27A, SCA27B, Tg(tetO-MAPT*P301L)4510Kha |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- protein binding
- heparin binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- spinocerebellar ataxia 27A
- paroxysmal dyskinesia
- late-onset spinocerebellar ataxia type 27B
- drug-induced liver disease
- ataxia
- hereditary disorder
- preeclampsia
- cerebellar ataxia
- nystagmus
regulates
- FOS
- ERK1/2
- caspase 3/7
- Na+
role in cell
- phosphorylation in
- plasticity
- recycling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- nervous system development
- cell-cell signaling
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- growth factor activity
- protein binding