Man1b1 Gene Summary [Mouse]
Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Acts upstream of or within ERAD pathway. Predicted to be located in cytoplasmic vesicle and endoplasmic reticulum quality control compartment. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in Rafiq syndrome. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Man1b1 |
| Official Name | mannosidase, alpha, class 1B, member 1 [Source:MGI Symbol;Acc:MGI:2684954] |
| Ensembl ID | ENSMUSG00000036646 |
| Bio databases IDs | |
| Aliases | mannosidase, alpha, class 1B, member 1 |
| Synonyms | E430019H13Rik, ERMAN1, ER MANI, Gm108, Image:3498155, LOC124906816, LOC227619, MANA-ER, mannosidase alpha class 1B member 1, mannosidase, alpha, class 1B, member 1, mannosidase α class 1B member 1, mannosidase, α, class 1B, member 1, MRT15, RGD1563595 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Man1b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolase family 47
- mannosyl-oligosaccharide 1,2-alpha-mannosidase
- catalytic domain
- calcium ion binding
- Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive mental retardation type 15
- insulin-dependent diabetes mellitus
- hereditary disorder
- congenital disorder of glycosylation type 2 due to MAN1B1 deficiency
- coronary aneurysm
regulates
- Man9-GlcNAc
- TF
- SERPINA1
- oligosaccharide
role in cell
- retention in
- endoplasmic reticulum-associated degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Man1b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- protein glycosylation
- mannoprotein catabolic process
- oligosaccharide metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum quality control compartment
- cytoplasmic vesicle
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- mannosyl-oligosaccharide 1,2-alpha-mannosidase activity