Zgpat Gene Summary [Mouse]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; gut epithelium; peripheral nervous system ganglion; and respiratory system. Orthologous to human ZGPAT (zinc finger CCCH-type and G-patch domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zgpat |
| Official Name | zinc finger, CCCH-type with G patch domain [Source:MGI Symbol;Acc:MGI:2449939] |
| Ensembl ID | ENSMUSG00000027582 |
| Bio databases IDs | |
| Aliases | zinc finger, CCCH-type with G patch domain |
| Synonyms | 1500006I01Rik, GPATC6, GPATCH6, KIAA1847, RGD1310801, ZC3H9, ZC3HDC9, zinc finger CCCH-type and G-patch domain containing, zinc finger, CCCH-type with G patch domain, ZIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zgpat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- G-patch domain
- CCCH-type zinc finger
- nucleic acid binding
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- RNA-binding, Nab2-type zinc finger
- double-stranded DNA binding
- zinc finger domain
- Tudor domain superfamily
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- liver cancer
- hepatitis B virus-related hepatocellular carcinoma
- prostatic carcinoma
- prostate cancer
- refractive error
- breast carcinoma
- inflammatory bowel disease
- ulcerative colitis
role in cell
- expression in
- proliferation
- growth
- binding in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zgpat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of epidermal growth factor-activated receptor activity
- negative regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity