Cyth1 Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within establishment of epithelial cell polarity. Located in bicellular tight junction; cytoplasmic side of plasma membrane; and cytosol. Is expressed in nervous system. Orthologous to human CYTH1 (cytohesin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyth1 |
| Official Name | cytohesin 1 [Source:MGI Symbol;Acc:MGI:1334257] |
| Ensembl ID | ENSMUSG00000017132 |
| Bio databases IDs | |
| Aliases | cytohesin 1 |
| Synonyms | B2-1, CLM1, CTH-1, CYTIP, CYTOHESIN-1, D17S811E, PSCD1, SEC7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyth1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sec7
- Sec7 domain
- guanyl-nucleotide exchange factor
- PH domain
- coiled-coil domain
- protein binding
- Pleckstrin homology-like domain
- basic domain
- guanine nucleotide exchange factor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Parkinson disease
- dysmyelination
- severe acute respiratory syndrome
- Huntington disease
- atrial fibrillation
- ulcerative colitis
- cleft lip
role in cell
- adhesion
- binding
- synaptic transmission
- transformation
- dissociation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic regions
- cell cortex
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- cytoplasmic face of plasma membrane
- Golgi membrane
- neuromuscular junctions
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyth1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- regulation of ARF protein signal transduction
- establishment of epithelial cell polarity
- regulation of cell adhesion
Cellular Component
Where in the cell the gene product is active
- tight junction
- adherens junction
- cytoplasm
- cytosol
- Golgi membrane
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- lipid binding