Alppl2 Gene Summary [Mouse]
Enables alkaline phosphatase activity. Located in myofibril. Is expressed in early conceptus; intestine; and testis. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alppl2 |
| Official Name | alkaline phosphatase, placental-like 2 [Source:MGI Symbol;Acc:MGI:108009] |
| Ensembl ID | ENSMUSG00000026246 |
| Bio databases IDs | |
| Aliases | alkaline phosphatase, placental-like 2 |
| Synonyms | Akp5, alkaline phosphatase, placental, alkaline phosphatase, placental-like 2, Alpg, Alpp, C77216, D1Ertd816e, EAP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alppl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- alkaline phosphatase
- Alkaline phosphatase homologues
- protease binding
- phosphatase
Pathways
Biological processes and signaling networks where the Alppl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- growth failure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- myofibrils