icon_0328_cc_gen_hmr_bacteria-s

Osteoarthritis Pathway

Osteoarthritis is the progressive degradation of joints such as the knee, with an endpoint of pain and complete loss of function. Joints are characterized by cartilage which forms the durable lubricating surface between two bones, and has limited metabolic, replicative, and repair capacity. Cartilage occupies an intermediate developmental state, as most bone develops from cartilage, but some cartilage is specifically arrested in this process (ossification) to provide the stable adult tissue. Chondrocytes are the main or only cell type within cartilage, secreting and enveloping themselves in a complex extracellular matrix composed of, among others, collagen (mostly type II), aggrecan, hyaluronan, lubricin, and fibronectin.Major risk factors for osteoarthritis are age, injury, obesity, inflammation, and lack of regular exercise...

Osteoarthritis Pathway

Pathway Summary

Osteoarthritis is the progressive degradation of joints such as the knee, with an endpoint of pain and complete loss of function. Joints are characterized by cartilage which forms the durable lubricating surface between two bones, and has limited metabolic, replicative, and repair capacity. Cartilage occupies an intermediate developmental state, as most bone develops from cartilage, but some cartilage is specifically arrested in this process (ossification) to provide the stable adult tissue. Chondrocytes are the main or only cell type within cartilage, secreting and enveloping themselves in a complex extracellular matrix composed of, among others, collagen (mostly type II), aggrecan, hyaluronan, lubricin, and fibronectin.Major risk factors for osteoarthritis are age, injury, obesity, inflammation, and lack of regular exercise. With age, the repair capability of cartilage declines dramatically, while regular moderate loading via exercise releases beneficial factors such as TGFβ. Chondrocytes, in order to effect any repair, need to secrete a variety of degradative enzymes to escape their matrix capsule, thus there is a fine balance between repair and degradation. While osteoarthritis involves other tissues of the joint, such as synovial fibroblasts and immune cells, most work has focused on chondrocytes, which are found to undergo complex changes, including extensive degradative enzyme secretion, hypertrophy, and apoptosis, along with the formation of osteophytes from other mesenchymal stem cells. This all closely resembles the normal developmental transition from cartilage to bone, which has thus served as a major focus and model of research into the molecular mechanisms of osteoarthritis.Chondrocytes have two major axes of transcriptional regulation, focused on SOX9 as a protective, stabilizing factor, and RUNX2 as a pro-development, pro-degradation, pro-osteoarthritis factor. These axes are mutually inhibitory, and respond to many signals and pathways, principally the SMAD2/3 pathway for SOX9, downstream from TGFβ stimulation, and the SMAD1/5/8 and NFκB pathways, induced by BMP growth factors, IL1β, matrix fragments and other danger signals (DAMPS), and by inflammation in general, for RUNX2.The RUNX2 and related pro-osteoarthritis factors induce a large variety of effector proteins, such as metalloproteases (MMPs and ADAMTSs), further inflammatory cytokines, and bone-promoting factors such as osteocalcin and osteopontin. Thus the pro-osteoarthritis pathways generate autocrine self-activating loops which can, unless countered by other events, and degrade cartilage to the point of symptomatic decline and destruction.

Osteoarthritis Pathway Genes list

Explore Genes related to Osteoarthritis Pathway

Products related to Osteoarthritis Pathway

Explore products related to Osteoarthritis Pathway
GeneGlobe ID: UPHS-014Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Signal Transduction PathwayFinder
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-012Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Apoptosis
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-014Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Signal Transduction PathwayFinder
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-011Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Inflammatory Cytokines & Receptors
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-012Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Apoptosis
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-011Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Inflammatory Cytokines & Receptors
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-013Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Extracellular Matrix & Adhesion Molecules
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-013Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Extracellular Matrix & Adhesion Molecules
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PAHS-011Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Inflammatory Cytokines & Receptors
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-012Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Apoptosis
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-013Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Extracellular Matrix & Adhesion Molecules
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-014Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Signal Transduction PathwayFinder™
RT2 Profiler PCR Array
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.