Coq3 Gene Summary [Mouse]
Predicted to enable 3-demethylubiquinol 3-O-methyltransferase activity and polyprenyldihydroxybenzoate methyltransferase activity. Predicted to be involved in glycerol metabolic process; methylation; and ubiquinone biosynthetic process. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in heart and heart right ventricle. Orthologous to human COQ3 (coenzyme Q3, methyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coq3 |
| Official Name | coenzyme Q3 methyltransferase [Source:MGI Symbol;Acc:MGI:101813] |
| Ensembl ID | ENSMUSG00000028247 |
| Bio databases IDs | |
| Aliases | coenzyme Q3 methyltransferase |
| Synonyms | 4732433J24, bA9819.1, coenzyme Q3 methyltransferase, coenzyme Q3, methyltransferase, DHHBMT, DHHBMTASE, UG0215E05 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Coq3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquinone biosynthesis O-methyltransferase
- O-methyltransferase
- 3-demethylubiquinone-9 3-O-methyltransferase
- hexaprenyldihydroxybenzoate methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Coq3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol metabolic process
- ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate
- ubiquinone biosynthetic process
- methylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- extrinsic to mitochondrial inner membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- O-methyltransferase activity
- protein binding
- polyprenyldihydroxybenzoate methyltransferase activity
- 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity