Gnrhr Gene Summary [Mouse]
Predicted to enable gonadotropin-releasing hormone receptor activity and growth hormone-releasing hormone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to hormone stimulus; and negative regulation of cell population proliferation. Predicted to be active in plasma membrane. Is expressed in several structures, including adenohypophysis; jaw; mandibular process; and ovary. Used to study hypogonadotropic hypogonadism 7 with or without anosmia. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to human GNRHR (gonadotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gnrhr |
| Official Name | gonadotropin releasing hormone receptor [Source:MGI Symbol;Acc:MGI:95790] |
| Ensembl ID | ENSMUSG00000029255 |
| Bio databases IDs | |
| Aliases | gonadotropin releasing hormone receptor |
| Synonyms | GH1, GnRH-I, GNRHR1, Gnrh receptor, gonadotropin releasing hormone receptor, GRHR, HH7, LHRHR, LHRH Receptor, LRHR, Presomatotropin, type I GNRH, type I GNRH receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gnrhr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- growth hormone-releasing hormone receptor
- gonadotropin-releasing hormone receptor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gnrhr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart disease
- prostate cancer
- metastasis
- obesity
- breast cancer
- perimenopausal breast cancer
- inflammatory invasive breast carcinoma
- lymphoma
- endometriosis
- bilateral breast carcinoma
role in cell
- apoptosis
- cell death
- production in
- transactivation in
- proliferation
- mobilization in
- remodeling
- growth
- adhesion
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
- Endoplasmic Reticulum
- motor endplates
- perikaryon
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gnrhr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to gonadotropin-releasing hormone
- G-protein coupled receptor signaling pathway
- gonadotropin secretion
- cellular response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- gonadotropin-releasing hormone receptor activity
- peptide binding