Hyal4 Gene Summary [Mouse]
Enables hyalurononglucosaminidase activity. Acts upstream of or within chondroitin sulfate proteoglycan catabolic process. Located in cell surface. Is expressed in ductus deferens; embryo; and testis. Orthologous to human HYAL4 (hyaluronidase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hyal4 |
| Official Name | hyaluronoglucosaminidase 4 [Source:MGI Symbol;Acc:MGI:1924292] |
| Ensembl ID | ENSMUSG00000029680 |
| Bio databases IDs | |
| Aliases | hyaluronoglucosaminidase 4 |
| Synonyms | 4632428M18RIK, CSHY, hyaluronidase 4, hyaluronoglucosaminidase 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hyal4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexosaminidase
- enzyme
- protein binding
- hyalurononglucosaminidase
- hyaluronidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- unilateral anterior cruciate ligament rupture
- osteoarthritis
- gingival recession
- dry eye syndrome
- prostatic disease
- knee osteoarthritis
- dry eye
- retinopathy of prematurity
- pain
- periodontitis
regulates
- chondroitin sulfate
- glycosaminoglycan
role in cell
- adhesion
- emigration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- lysosome
- sperm head
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hyal4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- chondroitin sulfate catabolic process
- hyaluronan catabolic process
- glycosaminoglycan catabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- cytoplasmic vesicle
- cell surface
Molecular Function
What the gene product does at the molecular level
- hyalurononglucosaminidase activity