Nek4 Gene Summary [Mouse]
Enables manganese ion binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm. Is expressed in seminiferous tubule; spermatid; spermatocyte; and testis. Orthologous to human NEK4 (NIMA related kinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nek4 |
| Official Name | NIMA (never in mitosis gene a)-related expressed kinase 4 [Source:MGI Symbol;Acc:MGI:1344404] |
| Ensembl ID | ENSMUSG00000021918 |
| Bio databases IDs | |
| Aliases | NIMA (never in mitosis gene a)-related expressed kinase 4 |
| Synonyms | NIMA (never in mitosis gene a)-related expressed kinase 4, NIMA-related kinase 4, NRK2, pp12301, STK2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nek4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Protein kinase domain
- manganese ion binding
- zDHHC ankyrin repeat binding domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- metastasis
- polycystic ovary syndrome
- pervasive developmental disorder
- ciliopathy
regulated by
- monocyte-derived macrophages
- Exendin4
- HGF
role in cell
- expression in
- formation
- formation in
- phosphorylation in
- cell viability
- replicative senescence
- cell cycle progression
- DNA damage response
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ciliary transition zone
- Cytoplasm
- basal bodies
- cytosol
- ciliary rootlet
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nek4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of transcription, DNA-dependent
- response to DNA damage stimulus
- protein phosphorylation
- mitotic cell cycle
- regulation of cellular senescence
Cellular Component
Where in the cell the gene product is active
- ciliary rootlet
- microtubule-based flagellar cytoplasm
- cytoplasm
- cilium basal body
- cytosol
- ciliary transition zone
Molecular Function
What the gene product does at the molecular level
- ATP binding
- manganese ion binding
- protein serine/threonine kinase activity