Gkn1 Gene Summary [Mouse]
Enables growth factor activity. Acts upstream of or within positive regulation of cell population proliferation. Located in secretory granule. Is expressed in several structures, including aorta; gut; quadriceps femoris muscle; reproductive system; and sciatic nerve. Orthologous to human GKN1 (gastrokine 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gkn1 |
| Official Name | gastrokine 1 [Source:MGI Symbol;Acc:MGI:1913533] |
| Ensembl ID | ENSMUSG00000030050 |
| Bio databases IDs | |
| Aliases | gastrokine 1 |
| Synonyms | 2200002K21Rik, AMP-18, BRICD1, Fov, gastrokine 1 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gkn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BRICHOS domain
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
phenotypes
- abnormal cranium morphology
- abnormal eye morphology
- abnormal heart morphology
- abnormal kidney morphology
- abnormal mandible morphology
- enlarged heart
- female infertility
- hydrometra
- increased lean body mass
- small superior vagus ganglion
- decreased circulating insulin level
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granules