Cdx1 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity. Involved in regulation of somitogenesis. Acts upstream of or within anterior/posterior pattern specification; bone morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo mesenchyme; genitourinary system; and intestine. Orthologous to human CDX1 (caudal type homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdx1 |
| Official Name | caudal type homeobox 1 [Source:MGI Symbol;Acc:MGI:88360] |
| Ensembl ID | ENSMUSG00000024619 |
| Bio databases IDs | |
| Aliases | caudal type homeobox 1 |
| Synonyms | caudal type homeo box 1, Cdx, Cdxa |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- DNA binding domain
- nucleic acid binding
- Caudal like protein activation region
- double-stranded DNA binding
- methyl-CpG binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Cdx1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Barrett syndrome
- colon epithelial cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- colorectal cancer
- rectum cancer
- colon carcinoma
role in cell
- proliferation
- expression in
- cell death
- apoptosis
- growth
- quantity
- migration
- accumulation
- tumorigenicity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- anterior/posterior axis specification
- regulation of somitogenesis
- bone morphogenesis
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- methyl-CpG binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity