Slco1a4 Gene Summary [Mouse]
Enables organic anion transmembrane transporter activity. Acts upstream of or within monoatomic anion transport. Located in membrane. Is expressed in brain and liver. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slco1a4 |
| Official Name | solute carrier organic anion transporter family, member 1a4 [Source:MGI Symbol;Acc:MGI:1351896] |
| Ensembl ID | ENSMUSG00000030237 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family, member 1a4 |
| Synonyms | Brain digoxin carrier, OATP1A4, OATP2, Organic anion transporting polypeptide 5, SLC21A5, Slco1a2, solute carrier organic anion transporter family, member 1a4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slco1a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- sodium-independent organic anion transporter
- Major Facilitator Superfamily
- bile acid transporter
- KAZAL_FS
- organic anion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cholestasis
regulated by
- forskolin
- pregnenolone carbonitrile
- TNF
- lipopolysaccharide
- diethylstilbestrol
- 8-bromo-cAMP
- PKA catalytic subunit
- dexamethasone
- carbon tetrachloride
- DMP904
regulates
- Slco1a4
- bile salt
- atorvastatin
- steroid
- anion
- digoxin
- bilirubin
- levothyroxine
- L-glutamic acid
- taurocholic acid
role in cell
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basolateral membrane
- basal membrane
- sinusoidal membrane
- brush border