Slco1a4 Gene Summary [Rat]
Enables bile acid transmembrane transporter activity. Involved in cellular response to xenobiotic stimulus; response to estrogen; and sodium-independent organic anion transport. Located in basal plasma membrane. Biomarker of Dubin-Johnson syndrome; cholestasis; and steatotic liver disease. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slco1a4 |
| Official Name | solute carrier organic anion transporter family, member 1a4 [Source:RGD Symbol;Acc:621389] |
| Ensembl ID | ENSRNOG00000047493 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family, member 1a4 |
| Synonyms | Brain digoxin carrier, OATP1A4, OATP2, Organic anion transporting polypeptide 5, SLC21A5, Slco1a2, solute carrier organic anion transporter family, member 1a4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slco1a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- sodium-independent organic anion transporter
- Major Facilitator Superfamily
- bile acid transporter
- KAZAL_FS
- organic anion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cholestasis
regulated by
- forskolin
- pregnenolone carbonitrile
- TNF
- lipopolysaccharide
- diethylstilbestrol
- 8-bromo-cAMP
- PKA catalytic subunit
- dexamethasone
- carbon tetrachloride
- DMP904
regulates
- Slco1a4
- bile salt
- atorvastatin
- steroid
- anion
- digoxin
- bilirubin
- levothyroxine
- L-glutamic acid
- taurocholic acid
role in cell
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basolateral membrane
- basal membrane
- sinusoidal membrane
- brush border