Gabra3 Gene Summary [Mouse]
Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in bipolar disorder and multiple sclerosis. Orthologous to human GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabra3 |
| Official Name | gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 [Source:MGI Symbol;Acc:MGI:95615] |
| Ensembl ID | ENSMUSG00000031343 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 |
| Synonyms | EPILX2, GABAA alpha 3, GABA A receptor alpha-3, Gaba A receptor subunit α 3, GABA A receptor α-3, GABAA α 3, gamma-aminobutyric acid type A receptor subunit alpha 3, α 3 gaba receptor, γ-aminobutyric acid type A receptor subunit alpha3, γ-aminobutyric acid type A receptor subunit α 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gabra3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- intracellular M3-M4 domain
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- benzodiazepine receptor
- ion channel
- anion channel
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- ligand-gated ion channel
- intracellular domain
- loop domain
Pathways
Biological processes and signaling networks where the Gabra3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- human immunodeficiency virus I infection
- HIV infection
- infection
- ischemic stroke
- disorder of coronary artery
- chronic kidney disease
- heart disease
- cancer
- Huntington disease
- psychosis
regulates
role in cell
- clustering in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- presynaptic membrane
- synaptic membrane
- vitreal membranes
- nerve ending
- synapse
- perikaryon
- dendrites
- postsynaptic density
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gabra3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- dendrite membrane
- postsynaptic membrane
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GABA-A receptor activity
- chloride channel activity
- benzodiazepine receptor activity
- GABA-gated chloride ion channel activity