icon_0328_cc_gen_hmr_bacteria-s

GABA Receptor Signaling

GABA is the main inhibitory neurotransmitter in the mammalian CNS. It is synthesized from glutamate by the enzyme L-glutamic acid decarboxylase. The GABA transporter GAT, located in the plasma membrane of nerve terminals and glial cells, plays an important role in the termination of synaptic transmission. GABA enters the cell via GAT and is then converted to gamma hydroxybutarate or succinate, the latter eventually entering the citrate cycle....

GABA Receptor Signaling

Pathway Summary

GABA is the main inhibitory neurotransmitter in the mammalian CNS. It is synthesized from glutamate by the enzyme L-glutamic acid decarboxylase. The GABA transporter GAT, located in the plasma membrane of nerve terminals and glial cells, plays an important role in the termination of synaptic transmission. GABA enters the cell via GAT and is then converted to gamma hydroxybutarate or succinate, the latter eventually entering the citrate cycle.There are three GABA receptors: GABA(A), GABA(B) and GABA(C) receptor. GABA(A) and GABA(C) receptors belong to the family of transmitter-gated ion channels while GABA(B) receptor is a G protein coupled receptor which is activated by baclofen. GABA(A) receptors are hetero-oligomeric Cl- channels that are modulated by barbiturates and benzodiazepines. GABA(A)R-associated protein (GABARAP) is localized in the golgi and plays a role in intracellular GABA (A) receptor transport via its ability to interact with N-ethylmaleimide-sensitive factor (NSF) and gephyrin (GPHN). Surface receptor number is important since it is a determinant of inhibitory synapse strength. It is controlled by removal of receptors from the membrane by interaction with the clathrin adaptor AP2 followed by recruitment into clathrin-coated pits. GABA(A) receptors can then be targeted for proteasomal degradation.

GABA Receptor Signaling Genes list

Explore Genes related to GABA Receptor Signaling

Products related to GABA Receptor Signaling

Explore products related to GABA Receptor Signaling
GeneGlobe ID: UPHS-060Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Neurotransmitter Receptors
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-060Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Neurotransmitter Receptors
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-036Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Neuronal Ion Channels
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-036Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Neuronal Ion Channels
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PAHS-152Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human GABA & Glutamate
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-060Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Neurotransmitter Receptors
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-036Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Neuronal Ion Channels
RT2 Profiler PCR Array
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.