Tpte Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Predicted to be active in cytosol. Is expressed in brain; eye; future spinal cord; surface ectoderm; and testis. Orthologous to several human genes including TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Tpte |
| Official Name | transmembrane phosphatase with tensin homology [Source:MGI Symbol;Acc:MGI:2446460] |
| Ensembl ID | ENSMUSG00000031481 |
| Bio databases IDs | |
| Aliases | transmembrane phosphatase with tensin homology |
| Synonyms | LOC102551183, Pten2, Tpte2, transmembrane phosphatase with tensin homology, transmembrane phosphoinositide 3-phosphatase and tensin homolog 2, Vsp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tpte often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C2 domain of PTEN tumour-suppressor protein
- PTP_DSP_cys
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- endoplasmic reticulum membrane