Saraf Gene Summary [Mouse]
Predicted to be involved in regulation of store-operated calcium entry. Predicted to be located in endoplasmic reticulum and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Is expressed in nervous system; nose; and tooth. Orthologous to human SARAF (store-operated calcium entry associated regulatory factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Saraf |
| Official Name | store-operated calcium entry-associated regulatory factor [Source:MGI Symbol;Acc:MGI:1915137] |
| Ensembl ID | ENSMUSG00000031532 |
| Bio databases IDs | |
| Aliases | store-operated calcium entry-associated regulatory factor |
| Synonyms | 1810045K07Rik, FOAP-7, HSPC035, LOC246218, MGC8721, store-operated calcium entry-associated regulatory factor, TMEM66, XTP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Saraf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCE-associated regulatory factor of calcium homoeostasis
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- organelle membrane contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Saraf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion transport
- regulation of store-operated calcium entry
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding