Cyb5r4 Gene Summary [Mouse]
Enables cytochrome-b5 reductase activity, acting on NAD(P)H. Acts upstream of or within several processes, including glucose homeostasis; insulin secretion; and response to antibiotic. Located in endoplasmic reticulum. Is expressed in metanephros; nervous system; sensory organ; submandibular gland primordium; and thymus primordium. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyb5r4 |
| Official Name | cytochrome b5 reductase 4 [Source:MGI Symbol;Acc:MGI:2386848] |
| Ensembl ID | ENSMUSG00000032872 |
| Bio databases IDs | |
| Aliases | cytochrome b5 reductase 4 |
| Synonyms | 2810034J18Rik, b5b5r, b5/b5r, B5+B5R, Cb5cb5r, cytochrome b5 reductase 4, Ncb5or |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyb5r4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- CS domain
- flavin adenine dinucleotide binding
- NADH or NADPH:heme protein oxidoreductase
- cytochrome-b5 reductase
- enzyme
- protein binding
- heme binding
- Oxidoreductase FAD-binding domain
- alpha-crystallin Hsps/p23-like
- NADPH oxidase
- Cytochrome b5-like Heme/Steroid binding domain
- Oxidoreductase NAD-binding domain
- NADPH-ferrihemoprotein reductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Endoplasmic Reticulum