Atf6 Gene Summary [Mouse]
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and protein heterodimerization activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; eye; liver; long bone; and tooth. Used to study achromatopsia 7. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atf6 |
| Official Name | activating transcription factor 6 [Source:MGI Symbol;Acc:MGI:1926157] |
| Ensembl ID | ENSMUSG00000026663 |
| Bio databases IDs | |
| Aliases | activating transcription factor 6 |
| Synonyms | 9130025P16RIK, 9630036G24, AA789574, ACHM7, activating transcription factor 6, activating transcription factor 6 β, ATF6A, ATF6 alpha, Atf6 (predicted), ATF6 α, ATP6alpha, ESTM49 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- nucleic acid binding
- transcription activation domain
- enzyme binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- identical protein binding
- zDHHC ankyrin repeat binding domain
- endoplasmic reticulum lumenal domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic helix-loop-helix-leucine zipper domain
- N-linked glycosylation site
- cytoplasmic domain
- double-stranded DNA binding
- lumenal domain
- transmembrane domain
- bZIP
- transcription factor activity
- protein heterodimerization
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Atf6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- arthritis
- diabetes mellitus
- Parkinson disease
- atopic dermatitis
- neoplasia
- foveal hypoplasia
- achromatopsia 7
- prostate cancer
- immunodeficiency
role in cell
- phosphorylation in
- activation in
- molecular cleavage in
- cell viability
- expression in
- induction in
- degradation in
- apoptosis
- proliferation
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- nuclear fraction
- nuclear membrane fraction
- perinuclear region
- cellular membrane
- filamentous network
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- nucleoplasm
- perinuclear space
- nuclear envelope
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- eye development
- signal transduction
- endoplasmic reticulum unfolded protein response
- positive regulation of apoptotic process
- protein folding
- positive regulation of transcription from RNA polymerase II promoter
- visual perception
- response to endoplasmic reticulum stress
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- nucleus
- membrane
- cytosol
- Golgi membrane
- endoplasmic reticulum
- Golgi apparatus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- enzyme binding