Atf3 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of ERK1 and ERK2 cascade; and regulation of transcription by RNA polymerase II. Acts upstream of or within gluconeogenesis; negative regulation of DNA-templated transcription; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and long bone. Orthologous to human ATF3 (activating transcription factor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atf3 |
| Official Name | activating transcription factor 3 [Source:MGI Symbol;Acc:MGI:109384] |
| Ensembl ID | ENSMUSG00000026628 |
| Bio databases IDs | |
| Aliases | activating transcription factor 3 |
| Synonyms | activating transcription factor 3, AIT3, LOC100911428, LRF-1, LRFI, LRG-21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- Basic region leucine zipper
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- protein homodimerization
- basic domain
- bZIP
- transcription factor activity
- protein heterodimerization
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Atf3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- neoplasia
- epithelial cancer
- cancer
- tumorigenesis
- nephrotoxic acute renal failure
- diabetic nephropathy
- sickle cell anemia
- bronchopulmonary dysplasia
- cardiac fibrosis
role in cell
- proliferation
- expression in
- phosphorylation in
- growth
- transactivation in
- production in
- survival
- activation in
- binding in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- basal bodies
- centrosome
- Golgi Apparatus
- nucleoplasm
- nucleoli
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- gluconeogenesis
- skeletal muscle cell differentiation
- endoplasmic reticulum unfolded protein response
- negative regulation of ERK1 and ERK2 cascade
- cellular response to amino acid starvation
- positive regulation of gene expression
- positive regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- response to endoplasmic reticulum stress
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity