Dhrs7c Gene Summary [Mouse]
Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in D-glucose import; intracellular calcium ion homeostasis; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Located in longitudinal sarcoplasmic reticulum and sarcoplasmic reticulum membrane. Orthologous to human DHRS7C (dehydrogenase/reductase 7C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Dhrs7c |
| Official Name | dehydrogenase/reductase (SDR family) member 7C [Source:MGI Symbol;Acc:MGI:1915710] |
| Ensembl ID | ENSMUSG00000033044 |
| Bio databases IDs | |
| Aliases | dehydrogenase/reductase (SDR family) member 7C |
| Synonyms | 1110001P11RIK, dehydrogenase/reductase 7C, RGD1306989, SDR32C2, SRP-35 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dhrs7c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- retinol dehydrogenase
- enzyme
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Dhrs7c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- Ca2+
- D-glucose
role in cell
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- longitudinal sarcoplasmic reticulum fraction
- sarcoplasmic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dhrs7c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- glucose import
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- longitudinal sarcoplasmic reticulum
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- retinol dehydrogenase activity
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor