Nlrp4b Gene Summary [Mouse]
Predicted to enable molecular adaptor activity. Predicted to be involved in negative regulation of innate immune response and regulation of inflammatory response. Predicted to be active in cytoplasm. Is expressed in ovary. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlrp4b |
| Official Name | NLR family, pyrin domain containing 4B [Source:MGI Symbol;Acc:MGI:3056570] |
| Ensembl ID | ENSMUSG00000034087 |
| Bio databases IDs | |
| Aliases | NLR family, pyrin domain containing 4B |
| Synonyms | AU022726, E330024M09, Nalp4b, Nalp-gamma, Nalp-γ, NLR family, pyrin domain containing 4B, RGD1559894 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nlrp4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- PAAD/DAPIN/Pyrin domain
- NOD2 winged helix domain
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat, ribonuclease inhibitor type
- Leucine rich repeat
- NACHT domain
- Death Domain Superfamily of protein-protein interaction domains
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- FIGLA
- tetradecanoylphorbol acetate
- Gstp1 (includes others)
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm