Tmem135 Gene Summary [Mouse]
Enables lipid transporter activity. Involved in several processes, including fatty acid derivative transport; fatty acid metabolic process; and regulation of mitochondrial fission. Acts upstream of or within several processes, including regulation of oxidative phosphorylation; response to food; and retinal pigment epithelium development. Located in lipid droplet; mitochondrion; and peroxisome. Is active in peroxisomal membrane. Orthologous to human TMEM135 (transmembrane protein 135). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem135 |
| Official Name | transmembrane protein 135 [Source:MGI Symbol;Acc:MGI:1920009] |
| Ensembl ID | ENSMUSG00000039428 |
| Bio databases IDs | |
| Aliases | transmembrane protein 135 |
| Synonyms | 2810439K08Rik, FLJ22104, PMP52, RGD1309948, transmembrane protein 135 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem135 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- N-terminal cysteine-rich region of Transmembrane protein 135
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- fracture of bone
- androgenic alopecia
- idiopathic scoliosis
- corneal astigmatism
regulated by
- CD24
regulates
- lipid
- cholesterol
- RAB8
- long chain fatty acid
- linolenic acid
- polyunsaturated fatty acids
- IFT20
role in cell
- accumulation in
- activation in
- organization
- ciliogenesis
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- lipid droplets
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem135 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- response to cold
- retinal pigment epithelium development
- regulation of oxidative phosphorylation
- peroxisome organization
- regulation of mitochondrial fission
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- lipid particle
- peroxisomal membrane
- peroxisome
- mitochondrial membrane