Ift20 Gene Summary [Mouse]
Enables opsin binding activity. Involved in regulation of organelle assembly; regulation of platelet-derived growth factor receptor-alpha signaling pathway; and spermatogenesis. Acts upstream of or within several processes, including morphogenesis of a polarized epithelium; plasma membrane bounded cell projection organization; and protein transport. Located in several cellular components, including ciliary base; microtubule cytoskeleton; and photoreceptor cell cilium. Part of intraciliary transport particle B. Is expressed in cranium. Orthologous to human IFT20 (intraflagellar transport 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ift20 |
| Official Name | intraflagellar transport 20 [Source:MGI Symbol;Acc:MGI:1915585] |
| Ensembl ID | ENSMUSG00000001105 |
| Bio databases IDs | |
| Aliases | intraflagellar transport 20 |
| Synonyms | 0610009H04RIK, intraflagellar transport 20, LOC90410, mIFT20, RGD1309400 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ift20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Intraflagellar transport complex B, subunit 20
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
role in cell
- production in
- expression in
- differentiation
- proliferation
- phosphorylation in
- number
- cell death
- migration
- binding in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- ciliary tip
- cilia
- manchette
- basal bodies
- centrosome
- Golgi Apparatus
- centriole
- microtubule organizing centers
- connecting cilia
- stereocilia
- Golgi membrane
- trans Golgi network
- cis Golgi networks
- acrosome
- neurites
- photoreceptor outer segments
- recycling endosomes
- early endosomes
- cytoplasmic vesicles
- microvilli
- dendrites
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ift20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transmembrane transport
- inner ear receptor stereocilium organization
- cilium morphogenesis
- cochlea development
- protein localization in Golgi apparatus
- neural precursor cell proliferation
- spermatogenesis
- smoothened signaling pathway
- visual learning
- positive regulation of flagellum assembly
- centrosome localization
- intraflagellar transport
- kidney development
- regulation of canonical Wnt receptor signaling pathway
- establishment of epithelial cell apical/basal polarity
- establishment of planar polarity
- regulation of autophagic vacuole assembly
- photoreceptor cell outer segment organization
- regulation of platelet-derived growth factor receptor-alpha signaling pathway
- cardiac muscle cell differentiation
- intraflagellar anterograde transport
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- cilium basal body
- Golgi membrane
- Golgi apparatus
- manchette
- photoreceptor outer segment
- dendrite terminus
- centrosome
- motile cilium
- cis-Golgi network
- microvillus
- cytoplasm
- centriole
- acrosomal vesicle
- cilium
- intraflagellar transport particle B
- stereocilium
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- opsin binding