Defb3 Gene Summary [Mouse]
Predicted to enable CCR6 chemokine receptor binding activity; chemoattractant activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Acts upstream of or within defense response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in skin. Orthologous to human DEFB4A (defensin beta 4A) and DEFB4B (defensin beta 4B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Defb3 |
| Official Name | defensin beta 3 [Source:MGI Symbol;Acc:MGI:1351612] |
| Ensembl ID | ENSMUSG00000039775 |
| Bio databases IDs | |
| Aliases | defensin beta 3 |
| Synonyms | BD-3, Beta-defensin 3, Defb103a, defensin beta 3, defensin β 3, Mbd3, β-defensin 3 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Defb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- phosphatidylinositol-4,5-bisphosphate binding
- Beta defensin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space