Tdrd6 Gene Summary [Mouse]

Involved in spermatogenesis and spliceosomal snRNP assembly. Acts upstream of or within germ cell development. Located in P granule; chromatoid body; and endoplasmic reticulum. Part of ribonucleoprotein complex. Is active in synapse. Is expressed in primary spermatocyte; spermatid; spermatocyte; and testis. Orthologous to human TDRD6 (tudor domain containing 6). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Tdrd6
Official Name
tudor domain containing 6 [Source:MGI Symbol;Acc:MGI:2679727]
Ensembl ID
ENSMUSG00000040140
Bio databases IDs NCBI: 210510 Ensembl: ENSMUSG00000040140
Aliases tudor domain containing 6
Synonyms bA446F17.4, CT41.2, NY-CO-45, SPATA36, TDR2, tudor domain containing 6
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tdrd6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Tudor domain
  • protein binding
  • Tudor domain superfamily

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • azoospermia
regulated by
regulates
  • snRNP
role in cell
  • apoptosis
  • development
  • abnormal morphology

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytoplasmic ribonucleoprotein granule
  • Endoplasmic Reticulum
  • cytosol
  • sister chromatids
  • synapse

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tdrd6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • spermatogenesis
  • P granule organization
  • piRNA metabolic process

Cellular Component

Where in the cell the gene product is active
  • chromatoid body
  • cytoplasm
  • P granule

Gene-Specific Assays for Results You Can Trust

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