Slc26a7 Gene Summary [Mouse]
Enables chloride channel activity and chloride:bicarbonate antiporter activity. Involved in several processes, including bicarbonate transport; carboxylic acid transport; and inorganic anion transmembrane transport. Acts upstream of or within chloride transport. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; brain; limb; respiratory system; and sensory organ. Used to study congenital hypothyroidism. Orthologous to human SLC26A7 (solute carrier family 26 member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc26a7 |
| Official Name | solute carrier family 26, member 7 [Source:MGI Symbol;Acc:MGI:2384791] |
| Ensembl ID | ENSMUSG00000040569 |
| Bio databases IDs | |
| Aliases | solute carrier family 26, member 7 |
| Synonyms | solute carrier family 26 member 7, solute carrier family 26, member 7, SUT2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc26a7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxalate transporter
- Sulfate permease family
- sulfate transporter
- high affinity sulphate transporter 1
- chloride transporter
- bicarbonate transporter
- sulphate transporter and anti-sigma factor antagonist domain
- anion transporter
- anion channel
- PRK11660
- chloride channel
- antiporter
- inorganic anion exchanger
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- schizophrenia
- metabolic acidosis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- diabetic nephropathy
- distal renal tubular acidosis
- renal tubular acidosis
- acidemia
- congenital hypothyroidism
regulates
- acid
- ion
- nitrate
- oxalic acid
- thyroid hormone
- chloride
- TSH
- iodide
- Cl-/HCO3- exchanger
- bicarbonate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- endosomes
- apical membrane
- basolateral membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc26a7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gastric acid secretion
- sulfate transport
- ion transport
- thyroid hormone generation
- nitrate transport
- iodide transport
- gluconate transmembrane transport
- oxalate transport
- chloride transport
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- endosome
- cytoplasm
- recycling endosome membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- oxalate transmembrane transporter activity
- chloride channel activity
- chloride transmembrane transporter activity
- bicarbonate transmembrane transporter activity
- sulfate transmembrane transporter activity