Ar Gene Summary [Mouse]
This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male animals. Loss of function in female animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015]
Details
| Type | Protein Coding |
| Official Symbol | Ar |
| Official Name | androgen receptor [Source:MGI Symbol;Acc:MGI:88064] |
| Ensembl ID | ENSMUSG00000046532 |
| Bio databases IDs | |
| Aliases | androgen receptor |
| Synonyms | AIS, Andr, androgen receptor, AW320017, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, Testosterone receptor, TFM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ar often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sumoylation motif
- steroid hormone receptor
- A/B region
- protein binding activity, bridging
- androgen receptor binding
- inhibitory domain
- transcription factor binding
- hormone binding domain
- Tau2 domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- binding function-3 domain
- nuclear receptor ligand binding domain
- ligand-dependent nuclear receptor
- glutamine repeat domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- nucleotide binding
- nuclear export signal
- DNA binding domain
- fxxlf motif
- beta-catenin binding
- nucleic acid binding
- protein binding
- tau-5 domain
- sequence-specific DNA binding
- polyproline motif
- androgen binding
- N-terminal transactivation domain
- steroid-binding domain
- hinge domain
- transcription factor activity
- transcription regulator
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- polyglycine repeat
- transcription activation domain
- AF-2 transcription activation domain
- chromatin binding
- AF-1 domain
- ligand-binding domain
- acetylation site
- alpha helix
- nuclear localization sequence
- enzyme binding
- protein domain specific binding
- receptor binding
- DNA binding
- tau domain
- tau1-core domain
- phosphorylation site
- ATPase binding
- binding protein
- double-stranded DNA binding
- polyglutamine repeat
- androgen receptor
- zinc finger domain
- Ligand-binding domain of nuclear hormone receptor
- C-terminal extension
Pathways
Biological processes and signaling networks where the Ar gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- metastatic breast cancer
- locally advanced breast cancer
- hormone receptor positive breast cancer
- advanced breast cancer
- cervical cancer
- non-small cell lung cancer
- glioblastoma
- metastatic renal cell carcinoma
- infection
role in cell
- mitogenesis
- proliferation
- expression in
- accumulation in
- phosphorylation in
- inhibition in
- size
- activation in
- cell death
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- raft fractions
- nuclear matrix fraction
- membrane fraction
- Cytoplasm
- cell surface
- perinuclear region
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- nucleoplasm
- perinuclear space
- nuclear speckles
- nuclear matrix
- DNA replication foci
- telomeres
- chromatin
- axons
- dendrites
- plasma
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ar gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of integrin biosynthetic process
- activation of prostate induction by androgen receptor signaling pathway
- male gonad development
- negative regulation of integrin biosynthetic process
- transcription from RNA polymerase II promoter
- positive regulation of epithelial cell proliferation involved in prostate gland development
- single fertilization
- positive regulation of NF-kappaB transcription factor activity
- regulation of developmental growth
- epithelial cell proliferation
- positive regulation of transcription, DNA-dependent
- in utero embryonic development
- male genitalia morphogenesis
- G-protein coupled receptor signaling pathway
- epithelial cell morphogenesis
- insulin-like growth factor receptor signaling pathway
- cell-cell signaling
- organ formation
- lateral sprouting involved in mammary gland duct morphogenesis
- positive regulation of gene expression
- negative regulation of epithelial cell proliferation
- Leydig cell differentiation
- multicellular organism growth
- prostate gland epithelium morphogenesis
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- regulation of systemic arterial blood pressure
- tertiary branching involved in mammary gland duct morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase III promoter
- epithelial cell differentiation involved in prostate gland development
- positive regulation of insulin-like growth factor receptor signaling pathway
- cellular response to testosterone stimulus
- negative regulation of transcription from RNA polymerase II promoter
- MAPK cascade
- mammary gland alveolus development
- seminiferous tubule development
- male somatic sex determination
- androgen receptor signaling pathway
- intracellular estrogen receptor signaling pathway
- intracellular receptor mediated signaling pathway
- positive regulation of phosphorylation
- signal transduction
- spermatogenesis
- morphogenesis of an epithelial fold
- prostate gland growth
- positive regulation of cell differentiation
- positive regulation of MAPK cascade
- cellular response to estrogen stimulus
- cellular response to steroid hormone stimulus
- intracellular steroid hormone receptor signaling pathway
- positive regulation of intracellular estrogen receptor signaling pathway
- negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- macromolecular complex
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- estrogen response element binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- androgen binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- beta-catenin binding
- steroid binding
- receptor binding
- transcription coactivator binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- G-protein coupled receptor activity
- sequence-specific DNA binding transcription factor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- POU domain binding
- RNA polymerase II basal transcription factor binding
- binding, bridging
- enzyme binding
- ATPase binding