Cd1d2 Gene Summary [Mouse]

This gene encodes a MHC class I-like molecule involved in the presentation of lipid antigens to T cells, and is involved in the activation of Natural Killer T (NKT) cells. The gene is highly similar to the CD1d1 antigen gene, which is located adjacent to this gene in a tail-to-tail fashion. This gene contains a frameshift and does not produce a functional product in the C57BL/6 strain. Alternatively splice transcript variants encoding different isoforms have been found in non-C57BL/6 strains. [provided by RefSeq, Jan 2014]

Details

Type
Polymorphic Pseudogene
Official Symbol
Cd1d2
Official Name
CD1d2 antigen [Source:MGI Symbol;Acc:MGI:107675]
Ensembl ID
ENSMUSG00000041750
Bio databases IDs NCBI: 12480 Ensembl: ENSMUSG00000041750
Aliases CD1d2 antigen
Synonyms Cd1b, CD1d2 antigen, Ly-38
Species
Mouse, Mus musculus

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd1d2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • lipid antigen binding
  • MHC-I family domain
  • Immunoglobulin C1-set domain
  • histone binding
  • immunoglobulin domain
  • cell adhesion molecule binding
  • exogenous lipid antigen binding

Pathways

Biological processes and signaling networks where the Cd1d2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • insulin-dependent diabetes mellitus
  • diabetes mellitus
regulated by
regulates
  • IL4
  • aldesleukin
role in cell
  • quantity
  • cytotoxicity
  • activation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Cytoplasm
  • cell surface
  • cellular membrane
  • lysosome
  • Endoplasmic Reticulum
  • plasma membrane extracellular face

Gene-Specific Assays for Results You Can Trust

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