Sptssb Gene Summary [Mouse]
Contributes to serine C-palmitoyltransferase activity. Acts upstream of or within ceramide biosynthetic process; endoplasmic reticulum organization; and regulation of serine C-palmitoyltransferase activity. Part of serine palmitoyltransferase complex. Is expressed in central nervous system; eye; genitourinary system; and gut. Orthologous to human SPTSSB (serine palmitoyltransferase small subunit B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sptssb |
| Official Name | serine palmitoyltransferase, small subunit B [Source:MGI Symbol;Acc:MGI:1913433] |
| Ensembl ID | ENSMUSG00000043461 |
| Bio databases IDs | |
| Aliases | serine palmitoyltransferase, small subunit B |
| Synonyms | 1110032A04Rik, ADMP, C3orf57, LOC100909705, serine palmitoyltransferase small subunit B, serine palmitoyltransferase, small subunit B, SSSPTB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sptssb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small subunit of serine palmitoyltransferase-like
- serine C-palmitoyltransferase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Sptssb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
role in cell
- quantity
- degeneration
- localization
- organization
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sptssb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sphingosine biosynthetic process
- ceramide biosynthetic process
- endoplasmic reticulum organization
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- serine C-palmitoyltransferase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine C-palmitoyltransferase activity