Flg2 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity and transition metal ion binding activity. Predicted to be involved in cell adhesion; epidermis morphogenesis; and establishment of skin barrier. Is active in cornified envelope. Human ortholog(s) of this gene implicated in peeling skin syndrome 6. Orthologous to human FLG2 (filaggrin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Flg2 |
| Official Name | filaggrin family member 2 [Source:MGI Symbol;Acc:MGI:3645678] |
| Ensembl ID | ENSMUSG00000049133 |
| Bio databases IDs | |
| Aliases | filaggrin family member 2 |
| Synonyms | EG229574, filaggrin family member 2 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S-100/ICaBP type calcium binding domain
- EF-hand domain pair
- EFh
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope