Tnip1 Gene Summary [Mouse]
Enables polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of canonical NF-kappaB signal transduction; positive regulation of defense response; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tnip1 |
| Official Name | TNFAIP3 interacting protein 1 [Source:MGI Symbol;Acc:MGI:1926194] |
| Ensembl ID | ENSMUSG00000020400 |
| Bio databases IDs | |
| Aliases | TNFAIP3 interacting protein 1 |
| Synonyms | ABIN, ABIN-1, NAF1, Nef, nip40-1, TNFAIP3 interacting protein 1, VAN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NEMO-binding domain
- Ciliary protein causing Leber congenital amaurosis disease
- protein kinase binding
- UBAN motif
- minimal active domain
- protein binding
- identical protein binding
- ABIN homology domain 2
- Domain of unknown function (DUF4200)
- phosphorylation site
Pathways
Biological processes and signaling networks where the Tnip1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- thrombocytopenia
- anemia
- acute myeloid leukemia
- Alzheimer disease
- rheumatoid arthritis
- systemic lupus erythematosus
- amyotrophic lateral sclerosis
- glomerulonephritis
- psoriasis
role in cell
- apoptosis
- cell death
- production in
- expression in
- activation in
- phosphorylation in
- binding in
- quantity
- loss
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein biosynthetic process
- positive regulation of inflammatory response
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- defense response
- leukocyte cell-cell adhesion
- regulation of transcription from RNA polymerase II promoter
- translation
- inflammatory response
- MyD88-dependent toll-like receptor signaling pathway
- cellular response to lipopolysaccharide
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- mitogen-activated protein kinase binding