Tnip1 Gene Summary [Mouse]
Enables polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of canonical NF-kappaB signal transduction; positive regulation of defense response; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tnip1 |
| Official Name | TNFAIP3 interacting protein 1 [Source:MGI Symbol;Acc:MGI:1926194] |
| Ensembl ID | ENSMUSG00000020400 |
| Bio databases IDs | |
| Aliases | TNFAIP3 interacting protein 1 |
| Synonyms | ABIN, ABIN-1, NAF1, Nef, nip40-1, TNFAIP3 interacting protein 1, VAN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NEMO-binding domain
- Ciliary protein causing Leber congenital amaurosis disease
- protein kinase binding
- UBAN motif
- minimal active domain
- protein binding
- identical protein binding
- ABIN homology domain 2
- Domain of unknown function (DUF4200)
- phosphorylation site
Pathways
Biological processes and signaling networks where the Tnip1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- thrombocytopenia
- anemia
- acute myeloid leukemia
- Alzheimer disease
- rheumatoid arthritis
- systemic lupus erythematosus
- amyotrophic lateral sclerosis
- glomerulonephritis
- psoriasis
phenotypes
- decreased circulating HDL cholesterol level
- decreased circulating cholesterol level
- decreased circulating fructosamine level
- decreased circulating glucose level
- decreased circulating iron level
- decreased circulating serum albumin level
- decreased erythrocyte cell number
- decreased heart rate
- decreased hematocrit
- decreased hemoglobin content
- decreased lymphocyte cell number
- increased basophil cell number
- increased circulating alkaline phosphatase level
- increased circulating aspartate transaminase level
- increased circulating potassium level
- increased large unstained cell number
- increased mean platelet volume
- increased monocyte cell number
- increased neutrophil cell number
- increased red blood cell distribution width
- increased spleen weight
- prolonged RR interval
- shortened QT interval
- thrombocytopenia
- abnormal Peyer's patch morphology
- abnormal basophil cell number
- abnormal blood vessel morphology
- abnormal circulating HDL cholesterol level
- abnormal circulating alkaline phosphatase level
- abnormal circulating cholesterol level
- abnormal circulating fructosamine level
- abnormal circulating glucose level
- abnormal circulating iron level
- abnormal circulating potassium level
- abnormal circulating serum albumin level
- abnormal complement pathway
- abnormal effector T cell morphology
- abnormal erythrocyte cell number
- abnormal hematocrit
- abnormal immune system morphology
- abnormal intestine morphology
- abnormal large unstained cell number
- abnormal lymphocyte cell number
- abnormal monocyte cell number
- abnormal neutrophil cell number
- abnormal plasma cell morphology
- abnormal platelet cell number
- abnormal platelet volume
- abnormal red blood cell distribution width
- abnormal spleen germinal center morphology
- abnormal spleen weight
- anemia
- bile duct hyperplasia
- cachexia
- decreased B cell number
- decreased B-2 B cell number
- decreased body size
- decreased body weight
- decreased circulating triglyceride level
- decreased fetal size
- decreased fetal weight
- decreased interleukin-12 secretion
- decreased interleukin-12b secretion
- enlarged lymph nodes
- enlarged spleen
- glomerulonephritis
- increased B cell number
- increased B cell proliferation
- increased B-1a cell number
- increased B-1b cell number
- increased IgA level
- increased IgE level
- increased IgG level
- increased IgG1 level
- increased IgG2a level
- increased IgG2b level
- increased IgG3 level
- increased IgM level
- increased T follicular helper cell number
- increased anti-double stranded DNA antibody level
- increased anti-nuclear antigen antibody level
- increased dendritic cell number
- increased fibroblast apoptosis
- increased germinal center B cell number
- increased granulocyte number
- increased hepatocyte apoptosis
- increased immunoglobulin level
- increased interleukin-12b secretion
- increased interleukin-6 secretion
- increased macrophage cell number
- increased plasma cell number
- increased spleen red pulp amount
- increased spleen white pulp amount
- increased susceptibility to induced colitis
- increased susceptibility to systemic lupus erythematosus
- increased tumor necrosis factor secretion
- increased urine protein level
- liver fibrosis
- liver hypoplasia
- lymph node hyperplasia
- pallor
- perinatal lethality incomplete penetrance
- premature death
- prenatal lethality incomplete penetrance
- spleen hyperplasia
- vasculitis
role in cell
- apoptosis
- cell death
- production in
- expression in
- activation in
- phosphorylation in
- binding in
- quantity
- loss
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein biosynthetic process
- positive regulation of inflammatory response
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- defense response
- leukocyte cell-cell adhesion
- regulation of transcription from RNA polymerase II promoter
- translation
- inflammatory response
- MyD88-dependent toll-like receptor signaling pathway
- cellular response to lipopolysaccharide
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- mitogen-activated protein kinase binding