Defb20 Gene Summary [Mouse]
Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and killing of cells of another organism. Predicted to be located in extracellular region. Is expressed in large intestine; submandibular gland; and testis. Orthologous to human DEFB128 (defensin beta 128). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Defb20 |
| Official Name | defensin beta 20 [Source:MGI Symbol;Acc:MGI:2442320] |
| Ensembl ID | ENSMUSG00000049560 |
| Bio databases IDs | |
| Aliases | defensin beta 20 |
| Synonyms | 9230107O10Rik, BD-20, Defb20, DEFB-28, defensin beta 128, defensin beta 20, defensin β 128, defensin β 20, hBD-28, mBD-20 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Defb20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta defensin
- protein binding
Pathways
Biological processes and signaling networks where the Defb20 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FAM209A
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Defb20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to Gram-negative bacterium
- innate immune response
- killing of cells of other organism
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding