Ucn2 Gene Summary [Mouse]
This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit increased insulin sensitivity and were protected against fat-induced insulin resistance. In addition, female mice lacking the encoded protein exhibit a significant increase in the basal daily rhythms of adrenocorticotropic hormone and corticosterone, and a significant decrease in fluid intake and depressive-like behavior. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | Ucn2 |
| Official Name | urocortin 2 [Source:MGI Symbol;Acc:MGI:2176375] |
| Ensembl ID | ENSMUSG00000049699 |
| Bio databases IDs | |
| Aliases | urocortin 2 |
| Synonyms | SRP, Ucn3, UCNI, Ucn II, Ucn iii, UR, urocortin 2, Urocortin 3, URP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ucn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hormone binding
- Corticotropin-releasing factor family
- G-protein-coupled receptor binding
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- left ventricular hypertrophy
- tachycardia
- reperfusion injury
- hypotension
- myocardial injury
- anorexia
- edema
role in cell
- activation in
- expression in
- production in
- quantity
- area
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ucn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to nutrient levels
- digestion
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- hormone-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- corticotropin-releasing hormone receptor 2 binding
- hormone binding
- corticotropin-releasing hormone receptor binding
- hormone activity