Otop2 Gene Summary [Mouse]

Enables proton channel activity. Involved in proton transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human OTOP2 (otopetrin 2). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Otop2
Official Name
otopetrin 2 [Source:MGI Symbol;Acc:MGI:2388365]
Ensembl ID
ENSMUSG00000050201
Bio databases IDs NCBI: 237987 Ensembl: ENSMUSG00000050201
Aliases otopetrin 2
Synonyms 4732464P15, otopetrin 2
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Otop2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Otopetrin
  • protein binding
  • ion channel
  • hydrogen ion channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • ulcerative colitis
  • colorectal cancer
regulated by
regulates
  • H+

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Unknown

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Otop2 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • hydrogen ion channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.