Cd79a Gene Summary [Mouse]
Enables transmembrane signaling receptor activity. Involved in B cell differentiation; B cell proliferation; and B cell receptor signaling pathway. Located in external side of plasma membrane; membrane raft; and multivesicular body. Part of B cell receptor complex. Is expressed in liver. Human ortholog(s) of this gene implicated in agammaglobulinemia 3. Orthologous to human CD79A (CD79a molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd79a |
| Official Name | CD79A antigen (immunoglobulin-associated alpha) [Source:MGI Symbol;Acc:MGI:101774] |
| Ensembl ID | ENSMUSG00000003379 |
| Bio databases IDs | |
| Aliases | CD79A antigen (immunoglobulin-associated alpha) |
| Synonyms | alpha4, BCR-IGA, CD79A antigen (immunoglobulin-associated alpha), CD79A antigen (immunoglobulin-associated α), Cd79al, CD79a molecule, IGA, IGAlpha, Ig-α, Immunoglobulin sheath alpha, Immunoglobulin sheath α, LOC687079, Ly-54, MB-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd79a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Antigen receptor homology 1 domain
- immunoglobulin domain
- alpha helix
- Immunoglobulin I-set domain
- linker domain
- tyrosine activation motif
- protein binding
- identical protein binding
- cytoplasmic domain
- Immunoglobulin like
- Immunoreceptor tyrosine-based activation motif
- intracellular domain
- cytosolic tail domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Cd79a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- B Cell Development
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- FcγRIIB Signaling in B Lymphocytes
- p70S6K Signaling
- PI3K Signaling in B Lymphocytes
- Primary Immunodeficiency Signaling
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- diabetic nephropathy
- Burkitt lymphoma
- precursor B-cell acute lymphoblastic leukemia
- diffuse large B-cell lymphoma
- leg type primary cutaneous diffuse large B-cell lymphoma
- classical Hodgkin lymphoma
- primary mediastinal large B-cell lymphoma
- Waldenström macroglobulinemia
- rheumatoid arthritis
role in cell
- expression in
- differentiation
- quantity
- phosphorylation in
- proliferation
- growth
- activation
- abnormal morphology
- survival
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- plasma membrane extracellular face
- multivesicular bodies
- membrane rafts
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd79a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- B cell proliferation
- adaptive immune response
- B cell activation
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- B cell receptor complex
- membrane raft
- external side of plasma membrane
- IgM B cell receptor complex
- multivesicular body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transmembrane signaling receptor activity