Foxd4 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; embryo endoderm; embryo mesoderm; lung; and neural ectoderm. Orthologous to several human genes including FOXD4 (forkhead box D4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxd4 |
| Official Name | forkhead box D4 [Source:MGI Symbol;Acc:MGI:1347467] |
| Ensembl ID | ENSMUSG00000051490 |
| Bio databases IDs | |
| Aliases | forkhead box D4 |
| Synonyms | Fkh2, FKHL9, forkhead box D4, FOXD4A, FREAC-5, HFH-6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- DNA bending protein
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- Forkhead domain
- FORKHEAD
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- anatomical structure morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- DNA binding, bending
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity