Raly Gene Summary [Mouse]
Enables RNA binding activity and transcription coregulator activity. Involved in cholesterol homeostasis and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human RALY (RALY heterogeneous nuclear ribonucleoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Raly |
| Official Name | hnRNP-associated with lethal yellow [Source:MGI Symbol;Acc:MGI:97850] |
| Ensembl ID | ENSMUSG00000027593 |
| Bio databases IDs | |
| Aliases | hnRNP-associated with lethal yellow |
| Synonyms | AI663842, hnRNP-associated with lethal yellow, HNRPCL2, Merc, P542, RALY heterogeneous nuclear ribonucleoprotein, RNA binding protein Raly/Merc |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Raly often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- RNA recognition motif
- transcription cofactor
- protein binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- glioma
- cancer
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- seborrheic keratosis
- dermatological disorder
- skin neoplasm
- skin neoplasia
- epithelial basal cell carcinoma
role in cell
- expression in
- migration
- invasion by
- downregulation in
- arginine methylation in
- interaction in
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Raly gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cholesterol homeostasis
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- RNA binding