Rnf26 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of defense response to virus; protein K11-linked ubiquitination; and protein localization to perinuclear region of cytoplasm. Predicted to be located in endoplasmic reticulum membrane. Is expressed in central nervous system; female associated reproductive structure; and urinary system. Orthologous to human RNF26 (ring finger protein 26). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Rnf26 |
| Official Name | ring finger protein 26 [Source:MGI Symbol;Acc:MGI:2388131] |
| Ensembl ID | ENSMUSG00000053128 |
| Bio databases IDs | |
| Aliases | ring finger protein 26 |
| Synonyms | 8030450I18Rik, ring finger protein 26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- enzyme
- Ring finger domain
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K11-linked ubiquitination
- endosome organization
- negative regulation of defense response to virus
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
- regulation of type I interferon production
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding