Sqstm1 Gene Summary [Mouse]
Enables several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; ionotropic glutamate receptor binding activity; and molecular condensate scaffold activity. Involved in several processes, including aggrephagy; brown fat cell proliferation; and positive regulation of long-term synaptic potentiation. Acts upstream of or within energy homeostasis; negative regulation of transcription by RNA polymerase II; and temperature homeostasis. Located in several cellular components, including aggresome; sperm midpiece; and vacuole. Is active in intracellular membraneless organelle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sqstm1 |
| Official Name | sequestosome 1 [Source:MGI Symbol;Acc:MGI:107931] |
| Ensembl ID | ENSMUSG00000015837 |
| Bio databases IDs | |
| Aliases | sequestosome 1 |
| Synonyms | A170, AC008393.2, DMRV, EBIAP, FTDALS3, NADGP, OSF-6, Osi, OSIL, Osip, Oxidative Stress, p60, p62, p62B, PDB1, PDB3, Pkc zeta interacting, Pkc ζ interacting, sequestosome 1, STAP, STONE14, Ubiquitin-binding protein a, ZIP, ZIP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sqstm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LC3-interacting region
- kinase inhibitory region domain
- protein binding activity, bridging
- transcription cofactor
- identical protein binding
- PB1
- Phox and Bem1 domain
- acidic cluster
- ATG8 binding domain
- receptor tyrosine kinase binding
- ubiquitin binding domain
- basic domain
- UBA domain-like superfamily
- ZZ
- ubiquitin protein ligase binding
- protein kinase binding
- signaling receptor activity
- nuclear export signal
- oligomerization domain
- SH2-domain binding
- protein kinase C binding
- enzyme binding
- ubiquitin binding
- protein binding
- ionotropic glutamate receptor binding
- zinc finger basic domain
- acidic domain
- TRAF6 binding domain
- PEST domain
- binding protein
- zinc finger domain
Pathways
Biological processes and signaling networks where the Sqstm1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- obesity
- epithelial cancer
- weight gain
- Paget disease of bone 3
- metastasis
- frontotemporal dementia and/or amyotrophic lateral sclerosis type 3
- astrocytosis
- childhood-onset neurodegeneration with ataxia, dystonia, and gaze palsy
role in cell
- expression in
- downregulation in
- replication in
- binding in
- migration
- growth
- proliferation
- phosphorylation in
- cell viability
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- glutaminergic synapse
- autophagosomal membrane
- amphisome
- intracellular membrane-bounded organelle
- cytoplasmic mRNA processing body
- organelle
- intracellular space
- perinuclear region
- Nucleus
- endosomes
- vesicles
- lysosome
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- nucleoplasm
- sperm midpiece
- synaptosomes
- synapse
- autophagic vacuoles
- cytoplasmic vesicles
- autolysosomes
- PML nuclear bodies
- chromatin
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sqstm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- positive regulation of long-term synaptic potentiation
- regulation of Ras protein signal transduction
- protein localization
- regulation of I-kappaB kinase/NF-kappaB cascade
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- response to ischemia
- protein targeting to vacuole involved in autophagy
- brown fat cell proliferation
- autophagy
- apoptotic process
- energy homeostasis
- endosomal transport
- negative regulation of protein ubiquitination
- aggrephagy
- macroautophagy
- intracellular signal transduction
- negative regulation of toll-like receptor 4 signaling pathway
- protein catabolic process
- macropexophagy
- macromitophagy
- mitochondrion degradation
- immune system process
- ubiquitin-dependent protein catabolic process
- positive regulation of autophagy
- protein import into nucleus
- positive regulation of apoptotic process
- temperature homeostasis
- positive regulation of protein phosphorylation
- cell differentiation
- regulation of mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- PML body
- pre-autophagosomal structure
- late endosome
- intracellular non-membrane-bounded organelle
- cytoplasmic mRNA processing body
- endoplasmic reticulum
- autophagic vacuole
- nucleoplasm
- extracellular vesicular exosome
- sperm midpiece
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- inclusion body
- aggresome
- sarcomere
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein kinase binding
- identical protein binding
- ionotropic glutamate receptor binding
- zinc ion binding
- signaling receptor activity
- SH2 domain binding
- ubiquitin protein ligase binding
- protein binding
- ubiquitin binding
- K63-linked polyubiquitin binding
- receptor tyrosine kinase binding
- protein binding, bridging
- enzyme binding