Ugt1a6a Gene Summary [Mouse]

Enables alpha-glucuronidase activity and glucuronosyltransferase activity. Involved in L-ascorbic acid biosynthetic process. Acts upstream of or within glucuronate metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human UGT1A6 (UDP glucuronosyltransferase family 1 member A6). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Ugt1a6a
Official Name
UDP glucuronosyltransferase 1 family, polypeptide A6A [Source:MGI Symbol;Acc:MGI:2137698]
Ensembl ID
ENSMUSG00000054545
Bio databases IDs NCBI: 94284 Ensembl: ENSMUSG00000054545
Aliases UDP glucuronosyltransferase 1 family, polypeptide A6A
Synonyms A9', UDP glucuronosyltransferase 1, UDP glucuronosyltransferase 1 family, polypeptide A6A, UDP glucuronosyltransferase 1 family, polypeptide A6B, UDP glucuronosyltransferase family 1 member A6, UDPGT, UDPGT 1-6, Ugt1, UGT1-06, UGT1.6, Ugt1a6, Ugt1a6a, Ugt1a6b, Ugt1a7, Ugt1a9
Species
Mouse, Mus musculus

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ugt1a6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • glycosyltransferase family 1 and related proteins with GTB topology
  • binding protein
  • glycosyltransferase, MGT family
  • enzyme binding
  • protein homodimerization
  • alpha-glucuronidase
  • enzyme
  • UDP-glucoronosyl and UDP-glucosyl transferase
  • protein heterodimerization
  • glucuronosyltransferase

Pathways

Biological processes and signaling networks where the Ugt1a6a gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • diabetic nephropathy
regulated by
  • cigarette smoke
  • oltipraz
  • ADCYAP1
  • Gstp1 (includes others)
  • 1,2-dithiole-3-thione
  • sulforafan
  • GATA2
  • cisplatin
  • butylhydroxybutylnitrosamine
  • NFE2L2
regulates
  • acetaminophen
  • 4-chlorobiphenyl
  • ascorbic acid
  • glucuronic acid
  • 1-naphthol
  • levothyroxine

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • intracellular membrane-bounded organelle
  • Endoplasmic Reticulum
  • microsome

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.