Kcnmb4 Gene Summary [Mouse]
Enables calcium-activated potassium channel activity. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Part of voltage-gated potassium channel complex. Is expressed in several structures, including central nervous system; hindlimb phalanx; naris; tarsus; and tooth. Orthologous to human KCNMB4 (potassium calcium-activated channel subfamily M regulatory beta subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnmb4 |
| Official Name | potassium large conductance calcium-activated channel, subfamily M, beta member 4 [Source:MGI Symbol;Acc:MGI:1913272] |
| Ensembl ID | ENSMUSG00000054934 |
| Bio databases IDs | |
| Aliases | potassium large conductance calcium-activated channel, subfamily M, beta member 4 |
| Synonyms | 1700058G18Rik, 2900045G12Rik, BKbeta4, Calcium activated potassium channel beta 4 subunit, Calcium activated potassium channel β 4 subunit, k(VCA)beta-4, k(VCA)β-4, potassium calcium-activated channel subfamily M regulatory beta subunit 4, potassium calcium-activated channel subfamily M regulatory β subunit 4, potassium large conductance calcium-activated channel, subfamily M, beta member 4, potassium large conductance calcium-activated channel, subfamily M, β member 4, slo-beta-4, slo-β-4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnmb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- Calcium-activated potassium channel, beta subunit
- calcium-activated potassium channel
- protein binding
- voltage-gated ion channel
- glycosylation site
- ion channel
Pathways
Biological processes and signaling networks where the Kcnmb4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atrial fibrillation
- atrial flutter
- nonconvulsive seizure
- insomnia
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
role in cell
- action potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnmb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- regulation of neurotransmitter secretion
- detection of calcium ion
- potassium ion transmembrane transport
- synaptic transmission
- regulation of action potential
- regulation of vasoconstriction
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium-activated potassium channel activity
- protein binding
- potassium channel regulator activity